The Weighing Machine

Historical Returns Database

Vertex Pharmaceuticals Incorporated (VRTX)

Year-to-date (December 31, 2025 to February 24, 2026), VRTX returned 7.51% versus 0.80% for the S&P 500 (SPY) and -1.05% for Nasdaq 100 (QQQ).

Ticker	Company Name	Total Returns	$1 turns into	Annualized Returns	Annualized Volatility	Sharpe Ratio
VRTX	Vertex Pharmaceuticals Incorporated	7.51%	$1.08	61.75%	33.47%	1.84
SPY	SPDR S&P 500 ETF Trust	0.80%	$1.01	5.40%	11.88%	0.45
QQQ	Invesco QQQ Trust, Series 1	-1.05%	$0.99	-6.75%	16.00%	-0.42

VRTX vs SPY vs QQQ - Past 12 Months

In the past 12 months (February 24, 2025 to February 24, 2026), VRTX returned 1.20% versus 16.44% for the S&P 500 (SPY) and 17.52% for Nasdaq 100 (QQQ).

Ticker	Company Name	Total Returns	$1 turns into	Annualized Returns	Annualized Volatility	Sharpe Ratio
VRTX	Vertex Pharmaceuticals Incorporated	1.20%	$1.01	1.20%	34.13%	0.04
SPY	SPDR S&P 500 ETF Trust	16.44%	$1.16	16.44%	19.39%	0.85
QQQ	Invesco QQQ Trust, Series 1	17.52%	$1.18	17.52%	23.35%	0.75

VRTX vs SPY vs QQQ - Past 5 Years

In the past 5 years (February 25, 2021 to February 24, 2026), VRTX returned 128.86% versus 92.58% for the S&P 500 (SPY) and 100.23% for Nasdaq 100 (QQQ). $1 invested in VRTX in 2021 became $2.29 in 2026.

Ticker	Company Name	Total Returns	$1 turns into	Annualized Returns	Annualized Volatility	Sharpe Ratio
VRTX	Vertex Pharmaceuticals Incorporated	128.86%	$2.29	18.01%	28.33%	0.64
SPY	SPDR S&P 500 ETF Trust	92.58%	$1.93	14.00%	17.03%	0.82
QQQ	Invesco QQQ Trust, Series 1	100.23%	$2.00	14.90%	22.54%	0.66

VRTX vs SPY vs QQQ - Past 10 Years

In the past 10 years (February 29, 2016 to February 24, 2026), VRTX had an annualized return of 19.03% versus 15.41% for the S&P 500 (SPY) and 20.38% for Nasdaq 100 (QQQ). $1 invested in VRTX in 2016 became $5.70 in 2026.

Ticker	Company Name	Total Returns	$1 turns into	Annualized Returns	Annualized Volatility	Sharpe Ratio
VRTX	Vertex Pharmaceuticals Incorporated	470.16%	$5.70	19.03%	33.38%	0.57
SPY	SPDR S&P 500 ETF Trust	318.96%	$4.19	15.41%	17.88%	0.86
QQQ	Invesco QQQ Trust, Series 1	538.45%	$6.38	20.38%	22.20%	0.92

VRTX vs SPY vs QQQ - Since April 2006

Since April 2006 (April 10, 2006 to February 24, 2026) VRTX had an annualized return of 14.37% versus 10.76% for the S&P 500 (SPY) and 15.23% for Nasdaq 100 (QQQ). $1 invested in VRTX in 2006 became $14.46 in 2026.

Ticker	Company Name	Total Returns	$1 turns into	Annualized Returns	Annualized Volatility	Sharpe Ratio
VRTX	Vertex Pharmaceuticals Incorporated	1345.52%	$14.46	14.37%	44.90%	0.32
SPY	SPDR S&P 500 ETF Trust	664.15%	$7.64	10.76%	19.44%	0.55
QQQ	Invesco QQQ Trust, Series 1	1575.96%	$16.76	15.23%	22.02%	0.69

Returns adjusted for splits and dividends.

Period start date is the earliest common trading day in the selected time period across all tickers.